Chunk #31 — Discussion and concluding remarks — Role of delta signaling in drug reward

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15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse.

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Data indicate that delta receptor activity reduces levels of anxiety and depressive-like behaviors, and that enkephalin is involved in this process (Chu Sin Chung and Kieffer, in press; Lutz and Kieffer, 2012; Pradhan et al., 2011), and it is likely that delta/pEnk signaling also regulates alcohol intake through similar mechanisms.