The extensive assessment battery for the COMBINE study included measures to capture medical history and physical exam, laboratory assessments (including blood glucose levels), adverse events, treatment-related expectancies, alcohol consumption, alcohol and drug involvement, motivation, craving, psychological and psychiatric assessments, social support, quality of life, and measures of treatment compliance and process. Primary assessments were administered at baseline and at weeks 8, 16, 26, 52, and 68 post randomization, with abbreviated assessments at 1, 2, 4, 6, 8, and 12 weeks. The primary outcomes for the main trial were percent days abstinent per month during treatment and time to first relapse to heavy drinking.
