Irish Case/Control Study of Schizophrenia(10), and the SGENE-plus consortium(11). In of a total of over 5000 patients with psychiatric disorders, the latter(11) also reported three copy number variants (CNVs) at the ZNF804A locus, a deletion in an individual with schizophrenia, a duplication in an individual with bipolar disorder, and a duplication in an individual with anxiety disorder. This contrasted with no CNVs at the locus in almost 40,000 controls (P=0.0016). From additional reported datasets, they also noted duplication CNVs in 3 people with autism, and an additional 3 CNVs out of a total of about 12000 controls, two of whom were under 18 and were therefore not past the characteristic age at onset for schizophrenia. Overall, the CNV data suggest that rare structural variants at the ZNF804A locus may also be involved in risk of a range of psychiatric disorders, though support for this is not unequivocal.
