None of these terms was significant for ARIC, though the term GO:0016918 “retinal binding”, which represents a subset of the term GO:0005501 was significant (p-value = 0.045). This term also includes the gene CRABP1 (Figure S3), which was significant for ARIC. Among the other genes in the term GO:0016918 in ARIC we found 3 common to OZALC-NAG (Figure S3). A posterior inspection of the ARIC study showed that the gene IGF2R, also had significant SNPs (i.e., rs8191772 with a p-value = 0.01). In contrast, no significant SNP tagged either CRABP2 nor UGT1A4.
