In the GWAS we corrected for diagnoses of the major psychiatric disorders studied in iPSYCH (see Supplementary Table 1 for distribution of psychiatric disorders among CUD cases and the control group). In addition, we evaluated the impact on the odds ratio for the index variant by leave-one-out analyses excluding psychiatric phenotypes one at a time in the association analysis (Methods). The odds ratio remained stable (Table 2), supporting that the association was independent of a diagnosis of the psychiatric disorders evaluated.
