CD, multiple sclerosis, and UC) and is near candidate genes C1orf106, CACNA1S, GPR25, and KIF21B. Genetic disruptions of voltage-gated calcium channels, including CACNA1S, are well-established susceptibility factors in psychiatric and neurological disorders (Schmunk & Gargus 2013; Heyes et al. 2015). KIF21B encodes a neuronal motor protein implicated in GABAA receptor trafficking (Labonte et al. 2014), in addition to having a suspected role in regulating inflammatory signaling in several lymphocyte subtypes (Goris et al. 2010).
