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Chunk #100 — Methods — Online Catalog and SMR, COLOC, TWAS

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Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.
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Next we ran COLOC18 (as downloaded from the Comprehensive R Archive Network) over the same set of GWAMA and eQTL studies. We used the Approximate Bayes Factor colocalization analysis, with effect sizes, their standard errors, allele frequencies and sample sizes as arguments. When the frequency information was missing from the GWAS, we filled in with data from the 1000 Genomes Project.