The following sections review the literature regarding brains of alcoholics from a neuropathological perspective and from the standpoint of results from MRI modalities including structural MRI, diffusion tensor imaging, MR spectroscopy, and functional MRI. The findings presented are not comprehensive but have been selected to indicate compromise of frontocerebellar circuitry and its nodes in alcoholism. For comprehensive reviews of the brain regions targeted by chronic alcoholism and associated neurological deficits, see (cf., Oscar-Berman et al., 1997; Mann et al., 2001; Chanraud et al., 2010a; Sullivan et al., 2010b).