HADS-D ≥ 8; 4) Combined disorder: both HADS-A ≥ 8 and HADS-D ≥ 8; and 5) Unclassified. This last group consisted of subjects with insufficient HADS score data. Some had total HADS scores but unavailable subscale scores, while others only had valid HADS-A or HADS-D score. To increase the specificity [9] and with intention identify individuals with moderate or severe disorder, analyses using cut-off score ≥ 11 were also performed, recommended for the first time 25 years ago [21]. Analyses were performed for men and women separately because previous studies have reported a gender difference regarding anxiety and the Val158Met polymorphism [8].
