For all analyses, MDD, recurrent MDD and MDD in females returned similar results: overlapping SNP-based heritability estimates; genetic correlations with consistent magnitude of effect, direction, and significance with six health-related traits; low trait variance explained (<1%) and overlapping effect size estimates in polygenic profiling analysis, and no genome-wide significant findings from GWAS meta-analysis (akin to similarly sized published GWAS of these phenotypes2,9).
