Despite the importance of striatal regions in addiction processes, genome-wide human omics studies of these brain regions are still missing. The striatum is divided into the ventral striatum (VS), consisting of the nucleus accumbens and olfactory tubercle; and the dorsal striatum, comprising the caudate nucleus (CN) and putamen (PUT) [13]. The nucleus accumbens is involved in mediating motivational processes such as aversion and reward, which play a significant role in the development and maintenance of substance use disorders (SUD) [13]. In addition to regulating motor function, the CN and PUT are involved in cognitive processes relevant for addiction, such as executive functioning and cognitive control, reinforcement learning and habit formation [14]. Analyses of omics data from striatal regions could complement the knowledge on global molecular changes in the neurocircuitry of addiction in AUD.
