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Chunk #17 — Introduction — Predictions from different mechanisms of maintaining genetic variation

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Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding.
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2010), since the rarer a variant is the less it can possibly be correlated with a common SNP in a sample of unrelated people (Wray 2005; Wray et al. 2011)1. To test (b), we examine the association between personality traits and the level of inbreeding in the ancestry of each individual as indexed by the extent to which their genome is in `runs of homozygosity' (i.e. homozygous stretches of DNA that can be observed in the offspring of even distant relatives (Keller et al. 2011b)).