Chunk #28 — Figure 3

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Extremely low-coverage sequencing and imputation increases power for genome-wide association studies.

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Genotype imputation accuracy in IHCS whole-exome data as a function of coverage. Illumina 1M genotype calls were used as a gold standard, restricting to 6070 SNPs in 10 distinct 5Mb regions (total of 50Mb) of the genome (see main text). Dotted lines denote results attained in 1000 Genomes simulations on the same SNP set.