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Chunk #16 — DATA & METHODS — The Fast Track Intervention Trial

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Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.
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The Fast Track intervention was a comprehensive prevention program for children at high risk for persistent antisocial behavior delivered over a 10-year period, when participating children were in the first through the tenth grades. Three successive cohorts of kindergarten children were enrolled in a randomized controlled trial in 1991, 1992, and 1993 to yield a sample of 891 children (445 in the intervention group and 446 in the control group). Figure 1 illustrates the Fast Track design. Fast Track participants were selected from four geographic sites: Durham, NC; Nashville, TN; rural PA; and Seattle, WA. Fifty-four elementary schools identified from high-crime, low-SES neighborhoods were divided into demographically matched sets within each site, and one set of schools was randomly assigned to intervention and one to control.