Chunk #35 — Results — Changes in expression of genes that were altered by alcohol drinking and also significantly differed between alcohol-naïve P and NP rats
Although Ingenuity pathway analysis did not reveal significant networks when all 62 genes were used in the analysis, one network emerged using only genes that changed in the opposite direction in the alcohol drinking group compared to the difference between the alcohol-naïve P vs. NP rats. There were several genes associated with Ubc (ubiquitin conjugating gene) that were lower in the P vs. NP rats and were higher in the ethanol vs. water group (listed in protein metabolic processes, cell adhesion, and inflammatory response categories; Table 8). Within this same network, there were several genes associated with Il6 (Interleuken 6) that were also significantly changed in the opposite direction with alcohol drinking relative to the naïve group (listed in inflammatory response category; Table 8).
