−0.099, p < 0.001, R2: 0.058) were associated with frequency of religious service attendance; any service attendance was less common in cannabis users (61.9%) than in non-users (81.0%) and in those meeting criteria for DSM-5 CUD (50.5%). Similar patterns were observed for any attendance (cannabis use: B: −0.124, p < 0.001, R2: 0.015; CUDsx: B: −0.136, p < 0.001, R2: 0.018) and weekly attendance (cannabis use: B: −0.214, p < 0.001, R2: 0.045; CUDsx: B: −0.135, p < 0.001, R2: 0.018). Frequency of religious service attendance moderated the association of the PRS with cannabis ever use and DSM-5 CUDsx but in the models that adjusted for age, sex, birth cohort, and ancestral PCs only (Model 1, Table 3). For cannabis ever use, interactions were observed between frequency of religious service attendance and PRS (p < 0.05 and p < 0.10 thresholds), and for DSM-5, interaction was observed between frequency of religious service attendance and PRS (p < 0.10 threshold). All PRS had a greater influence on cannabis ever use and DSM-5 CUDsx among those who less frequently attended religious services as compared to those who more frequently attended services (Fig. 2b). However, in models that also included cross-terms for all
