an LD threshold of r2 >= 0.25. Thus, PRS were constructed of SNPs that capture independent genetic association signals from the AlcGen and CHARGE+ GWAS. Following conventions for polygenic scoring using the pruning and thresholding approach (Bogdan et al., 2018), we calculated a series of scores in COGA that included SNPs meeting increasingly stringent p-value thresholds in the AlcGen and CHARGE+ discovery GWAS (Schumann et al., 2016; p < 0.50, p < 0.40, p < 0.30, p < 0.20, p < 0.10, p < 0.05, p < 0.01, p < 0.001, and p < 0.0001).
