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Chunk #9 — Methods — Existing methods — Trait-based association test involving the extended Simes procedure

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An efficient genome-wide association test for multivariate phenotypes based on the Fisher combination function.
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21]. Since me≤m, this new adjusted global p-value, defined as ptraits= min{mep(j)/je,j=1,…,m} is smaller than the Simes global p-value. Therefore, the TATES is more powerful than the Simes. A simulation study also showed that the TATES is more powerful than MANOVA. In this study, we conduct a comprehensive simulation study to compare this method with not only the classical methods reviewed above but also the proposed methods.