Chunk #24 — Results — Integrating Genetic and Network Data across Species to Inform GWA Discoveries — Identifying candidate susceptibility genes for T1D.
Figure 1A highlights how RPS26 is directly connected to a number of known T1D genes. For example, RPS26 is directly connected to a mouse ortholog of HLA-DRB1, a gene previously associated with T1D and highlighted in this present study as having liver expression values that are strongly associated with a highly replicated T1D SNP (Table 1). In fact, the genes comprising the local network structure around RPS26 are enriched for genes annotated as T1D genes, in addition to being enriched for genes operating in a number of pathways commonly associated with T1D (Table 3). On the other hand, whereas ERBB3 also resided in the context of a well defined subnetwork (Figure 1B), the genes comprising this subnetwork were not enriched for any T1D associated pathways.
