We begin by describing a specific brain system involved in emotion and action. We then review a theory connecting emotion-based rash action to this brain system and the empirical evidence supporting it. Then, we review evidence that an identified pattern of the functioning of two neurotransmitters in that brain system facilitates rash or ill-considered action. Once we have described that process, we consider gene polymorphisms that may relate to the levels of the relevant neurotransmitters.