Chunk #55 — Materials and Methods — Meta-Analysis Gene-set Enrichment of variaNT Associations (MAGENTA) — Step 3

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Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.

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This step-wise linear regression approach can be used to adjust for confounders on other types of variant to gene scoring metrics, and an appropriate set of potential confounders can be identified using the DGI permutation system described below.