The expression of factors associated with pluripotency as well as their tri-lineage differentiation capability, support the successful reprogramming of dermal fibroblasts to iPSC. Not surprisingly, BP and control iPSCs did not differ significantly in their transcriptional profiles. Although there were many similarities in gene expression, there were differences that will allow us to begin to examine the pathways previously suggested to be affected in BP and those identified in this study including calcium signaling and microRNA processing.
