Adipokines have emerged as FGF21-induced endocrine signals that also communicate back to stressed tissues. The upregulation of adiponectin currently is in the spotlight (40, 50, 51) although the role of the full spectrum of FGF21-controlled adipokines deserves investigation (Table 1). The many facets of the roles of FGF21 as a stress hormone that recruits the aid of adipose tissue adipocytes and its ramifications for stress-related diseases promise to be a broad and fruitful field of future study.
