The current study has some limitations. First, the gender composition of our HC and SZ groups was not fully matched. All participants in the SZ group were taking antipsychotic medications at the time of the MRI examination. Gender ratios were not statistically different between the two groups, and no correlation was found between FA values and antipsychotic medication dosage in the SZ group. However, gender difference and antipsychotic medication use are potential confounding factors for diffusion changes. Second, the sample size was relatively small. Last, no distortion correction was performed in DTI analysis. We offered new insight into relationship between microstructural abnormalities in callosal fibers and cognitive function in schizophrenia, but the results of our study should be confirmed in future studies using more subject with an appropriate control over FA value‐affecting factors.
