contribute to the pathogenesis of depression. Regarding synaptic signaling, CTNND1 functions in the glutamatergic excitatory synaptic signaling pathway during neuronal development38. With regard to synaptic plasticity, EPHB2 is an essential component of hippocampal synaptic plasticity39, and a number of studies have found that altering expression of EPHB2 in mouse models led to depression-like behavior, memory impairment, and defects of hippocampal neurogenesis and synaptic plasticity39,43. Likewise, P2RX7 drives synapse plasticity in the learned helplessness model of depression40 and has been previously implicated in depressive disorders40.
