PWAS) and showed evidence for colocalization. Only three genes were implicated in the PWAS; of these, CTNND1 was the only gene also implicated in the TWAS. In the PWAS, downregulation of CTNND1 protein expression in human dorsolateral prefrontal cortex was significantly associated with OCD risk (Z = −4.49, P = 7.11 × 10−6; Supplementary Table 13), consistent with the downregulation of CTNND1 gene expression in prefrontal cortex seen in the TWAS (Z = −6.86, P = 6.90 × 10−12; Supplementary Table 10). For a discussion of the overlap between the gene-findings with rare-coding variants in OCD, see Supplementary Table 6 and Supplementary Note 7.
