The large meta-analysis of AUD GWAS summary statistics (N = 48,545 AUD cases and 187,065 controls) from the Million Veterans Program (MVP)19, the Psychiatric Genetics consortium (PGC-SUD)12 and the Collaborative Studies on Genetics of Alcoholism (COGA)20 identified 1157 SNPs (31 independent lead SNPs) within or near 79 genes at 10 independent loci associated with AUD (Supplementary Figs. 1–4). We did not include UKB-AUDIT-P in this meta-analysis to specifically focus on AUD. Many of these loci were shared between the AUD GWAS meta-analysis and the DPW GWAS by Liu et al.11 who identified 81 independent loci represented by 5197 (>200 independent lead) SNPs. A total of 360 SNPs associated with AUD and DPW were in common (i.e., p < 5 × 10−8 in both GWAS) (Supplementary Fig. 5). A large and nominally significant proportion (45%) of AUD and DPW-associated SNPs were within intronic, UTR and non-coding regions of the genome (Supplementary Fig. 6).
