The purpose of the present paper is to extend the characterization of psychiatric, psychosocial, and physical health correlates of co-occurring cannabis and tobacco use in a large, nationally-representative epidemiologic study, the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). We hypothesized that psychiatric disorders, psychosocial problems that have public health relevance, and physical health problems would be more prevalent or severe in adults with co-occurring cannabis use disorders and nicotine dependence relative to adults with cannabis use disorders only, and relative to adults with nicotine dependence only.