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Chunk #39 — Discussion

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Cortical phase-amplitude coupling is key to the occurrence and treatment of freezing of gait.
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Increasing the number or the difficulty of concurrent tasks could induce FOG. Notably, most models focused on a feature of freezing and explained changes in other features as secondary. By comparison, the ‘interference model’ gave a more comprehensive picture stressing the joint participation of motor, cognitive and limbic circuits in FOG, which was further supported by later studies.34–36