To determine how well the genotyped SNPs represented the known variation (from the HapMap CEU database) in the regions of interest, we applied the program Tagger (de Bakker et al., 2005). Seven SNPs were genotyped across the 13 kb region containing NPY, extending 4 kb beyond each end of the gene (Table 2). The average r2 of these 7 SNPs with all of the 27 known HapMap SNPs (MAF≥0.10) in the 13 kb region was 0.96; r2 > 0.8 for 96% of the SNPs. The Leu/Pro7 polymorphism in NPY (rs16139) had a minor allele frequency (MAF) of 0.05.
