Transcripts involved in various aspects of Golgi/ER function (YIPF5, GCC1, COG4, COPZ1, VPS37C, LEPREL1, CPVL, SEMA3B) were increased. Also increased were transcripts encoding adaptins and an adaptin kinase (AP1M2, AP2A1, AP4B1, AAK1) associated with clathrin-coated vesicle endocytosis at the plasma membrane and in transport between the Golgi apparatus and the endosomal system. While transcripts encoding lysosomal enzymes (CTSD, DPP7) were increased, transcripts encoding proteins involved in synaptic vesicular trafficking (RIMBP2, ARL6IP4), transport from the late endosome to the lysosome (ASGR2, RAB9A), and a marker of cholesterol- and sphingolipid-rich lipid raft membrane microdomains involved in clathrin-independent endocytosis (FLOT1) were all decreased.
