× 10–37 for rs3791675 and PM = 1.8 × 10–14 versus PJ = 1.5 × 10–22 for rs720390 (Table 1). There were 11 loci harboring more than 2 associated SNPs, with a maximum number of 4, and the length of each locus varied substantially. For examples, three associated SNPs at a locus on chromosome 1 covered a genomic region of 1,134 kb, and the ACAN locus on chromosome 15, with three associated SNPs, only has a length of 32 kb (Table 1). Only considering the leading SNP(s) at each of the 36 loci (Table 1), there were 38 leading SNPs that, in total, explained 2.5% of phenotypic variance. However, taking all 87 jointly associated SNPs into account (38 leading and 49 additional), 4.1% of variance was explained, with the additional 49 SNPs explaining an additional 1.6% of the variance.
