that sample size is crucial in detecting findings with genome-wide significance due to a combination of two effects. Firstly, effects of individual (common) variants are typically rather small and, secondly, as a consequence of the large number of simultaneously investigated markers on the arrays, the single marker analyses have to be corrected for the large number of tests (Yang, Benyamin, McEvoy et al. 2010), allowing only those markers with the strongest effects to surpass the level of genome-wide significance.
