Beyond the ADH cluster, we identified two potential novel loci for MaxDrinks in the EA population. Rs1799876 at SERPINC1 on chromosome 1 was significantly associated with Maxdrinks in our Yale-Upenn EA sample (p=4.0 x 10-8). It became nearly significant after adjusting for rs1229984 (p=1.99 x 10-7). SERPINC1, serpin peptidase inhibitor, clade C gene has been associated with thrombosis-related phenotypes (Fischer et al., 2013). Rs2309169 on chromosome 2 was significantly associated with Maxdrinks in the Yale-Upenn EA samples (p= 5.6 x 10-9). It remained highly significant after adjusting rs1229984 (p = 2.1 x 10-9). This SNP is close to Ankyrin Repeat Domain 36 (ANKRD36). The link of ANKRD36 with Maxdrinks is still unknown.
