An initial genome-wide study of German male inpatients followed up by targeted genotyping of top SNPs and joint analysis provided evidence for association of alcohol dependence with two SNPs in the 3′ flanking region of PECR, peroxisomal trans-2-enoyl-coA [coenzyme A] reductase65, a member of the short-chain dehydrogenase family of enzymes. PECR is located within broad linkage peaks for several alcohol-related traits, including alcoholism66, comorbid alcoholism and depression67, level of response to alcohol68, and amplitude of the P3(00) response69, 70.
