During the last 7 years, with the rapid development of high-throughput technologies, omics data from diverse experimental platforms for human and other model organisms are accumulating exponentially. To satisfy the needs of biologists from different research areas, enrichment analysis tools should be directly applicable to data generated from different platforms and organisms. Thus, WebGestalt and some related tools (e.g. DAVID (2), FatiGO (3) and g:Profiler (4)) are constantly updated to support more organisms and platforms. The current version of WebGestalt supports 8 organisms and 201 gene identifiers from various databases and different experimental platforms (Figure 1).