exhibiting differential expression between THC and VEH groups (Begain and Dlgap2). Epigenetic changes of Dlgap2 (Chertkow-Deutsher et al, 2010) and Begain (Nagy et al, 2015) have already been implicated in neuropsychiatric phenotypes. However, a comparison of our gene set with a more comprehensive list of putative imprinted genes in rat, mouse, and human did not reveal enrichment for such loci. Nor did we observe evidence for preferential overlap of DMRs with annotated repeat elements in the rn4 genome, suggesting that alternate mechanisms likely underlie the maintenance of persistent methylation signatures in our identified DMRs.
