Chunk #38 — Online Methods — Stage 2 – follow-up in independent studies (quantitative lung function)

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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

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Summary statistics of a GWAS of FEV1, FVC and FEV1/FVC in 7,449 individuals were available from UKHLS (Supplementary Note). SNPs were genotyped using the Illumina Infinium HumanCoreExome BeadChip Kit and imputed against the same 1000 Genomes Project + UK10K combined imputation panel as used in discovery in this study. Association testing was performed separately for ever and never-smokers with covariates age, age2, sex height and ancestry principal components, as for Stage 1. We only included UKHLS results in the meta-analysis in this study if imputation info >0.5 and MAC >=3.