coined ethanol and stress response element (ESRE), was identified in the promoter region of several genes acutely induced by ethanol in the nematode, including several members of the heat shock protein family [16]. Accordingly, molecular chaperones were also differentially expressed in two strains of mice with divergent ethanol preference and up-regulated in the prefrontal cortex of alcoholics [54, 75]. Systematic in silico analysis of transcription factor binding sites over-represented in the promoter region of differentially expressed genes has been used in an attempt to identify transcription factors potentially orchestrating the regulation of candidate genes for ethanol preference and acute functional tolerance.
