In this study, we found that (1) ethanol suppressed hippocampal γ oscillations only at intoxicating concentrations; (2) This effect was reduced by a DR1 antagonist or a PKA inhibitor, completely prevented by Akt and GSK3β inhibitors, but enhanced by NMDA receptor antagonist; (3) MAPK and PI3-kinase inhibitors did not affect the effect of ethanol. These results suggest that the ethanol-induced suppression of γ is dependent on in the activation of DR1, PKA, Akt, and GSK3β and facilitated by the inhibition of NMDA receptors.
