We identified novel loci associated with SRE scores in both EA and AA samples. As additional samples with SRE data, specifically SRE-T, become available, individual loci and polygenic risk scores from such GWAS might explain even greater variance in LR. It will set the stage for future interventions that might aim to interrupt progression to AD (Roche and Ray, 2015, Schuckit et al., 2016). This boost in power necessitates further collection of SRE data. Since the assessment is brief and easily administered, and is included the PhenX tool kit (https://www.phenxtoolkit.org/), large biobanks and nation-wide data collection efforts are encouraged to gather data on SRE to capture greater variability to susceptibility to future problem drinking.
