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Chunk #49 — METHODS — Drug repositioning analysis.

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Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.
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CMap (https://clue.io/cmap) provides expression similarity scores for a specific expression profile with other drug-induced transcriptional profiles, including consensus transcriptional signatures of 83 drug classes, i.e., transcriptional profiles induced by 2,837 drugs grouped into 83 drug classes. Expression similarity is evaluated by means of scores that vary from −100 to 100, with −100 the most extreme opposite expression profile and 100 the most extreme similar expression profile.