A changing prescription opioid market, however, carries potential for unintended consequences as well, especially for those with prescription opioid use disorder (POUD). Indeed, a temporal association between a decreased supply of prescription opioids and increased prevalence of heroin use among persons with POUD has been reported (14, 15), and persons with POUD have noted that heroin became cheaper and more available than prescription opioids following the introduction of the abuse-deterrent formulation of Oxycontin (15, 16).
