There is also a decrease in α1 GABAA receptors and a significant increase in α4 subunit peptide in the synaptic fraction following chronic EtOH exposure. These results suggest that the regulation of intracellular trafficking following chronic EtOH administration may alter the subtypes of GABAA receptors on the cell surface and may account for changes in the pharmacological properties of GABAA receptors (Kumar et al. 2004) (Fig. 1).
