Implementation of these data release policies and processes are a topic of ongoing discussion and may need to be modified as risks of identifiability are better quantified for various data types, and as the size of the study increases. After initial processing of raw data (such as sequence reads and genotyping files), basic data quality checks are completed by the LDACC and statistical methods investigators, then data is released immediately through dbGaP. The first dbGaP data release, consisting of data from 62 individuals, occurred in June 2012. For the pilot phase of the project, which concluded in January 2013, the data set comprises genotype data from 190 individuals from which 1814 total tissues (from 47 separate tissue sites) were profiled by RNA-seq to a median depth of 80 million aligned reads. These data are in the process of being released to dbGaP, and we anticipate further releasing data two to four times per year until the project is completed. We expect total enrollment to over 400 by 2013, over 700 in 2014, and approximately 900 by the end of 2015.
