To validate these results, we analyzed ATAC-seq (chromatin) data from 13 cell types spanning the hematopoietic hierarchy in humans64. We validated 10 out of 14 top results (Table S9, Online Methods). The only immunological disease whose result was not validated was lupus; the top result for lupus in the ImmGen analysis was a myeloid cell type, while the largest and most significant enrichment in the hematopoiesis data set was a B cell enrichment, consistent with other genetic studies of this trait14.
