Novel loci found to be associated with alcohol consumption in this study include GCKR, CADM2 and FAM69C. GCKR encodes the glucokinase regulatory protein that is produced by hepatocytes and is responsible for phosphorylation of glucose in the liver. rs1260326 in GCKR is a coding missense SNP and this variant has been associated with over 25 metabolic traits including type II diabetes, fasting insulin levels and total cholesterol levels.46 CADM2 is a brain expressed gene encoding cell adhesion molecule 2 that has previously been associated with processing speed and educational attainment in the UKB sample and processing speed in the CHARGE consortium cohort.47, 48 A recent study of reproductive success and risk-taking propensity also found genome-wide significant associations with SNPs in CADM2.49 CADM2 has also been associated with lifetime cannabis use in a GWAS of ~32 000 individuals.50
