Chunk #46 — Materials and Methods — Pathway scores

Source

Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics.

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yes

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We also tested a generalization of the chi-squared method where the inverse χ12-quantile transformation of the p-value ranks was replaced by the inverse Gamma-quantile transformation with varying shape parameter. For shape parameter of 0.5, the results coincide with results from the chi-squared method.