Catalase, a peroxisomal enzyme, is a heme-containing antioxidant that converts two hydrogen peroxide (H2O2) molecules to water and oxygen and plays an important role in the maintenance of cellular redox homeostasis (119). However, the contribution of this pathway to the hepatic metabolism of ethanol is minimal. This is likely because the oxidation of ethanol by catalase depends on the presence of H2O2, which is of limited availability under physiological conditions (90).
