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Chunk #19 — 4. Discussion

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Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives.
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It is important to highlight there are clear differences between our sample and the child sample analyzed in Dick et al., 2006. Our adolescent patients were selected from admissions to a university substance abuse treatment program. Such adolescents might reasonably differ from conduct-disordered adolescents selected from families with a high-density of alcohol dependence. Our sample may represent adolescents with greater severity of conduct disorder, may suffer a greater severity of substance use problems or might differ in ways that facilitated their entry to treatment (refractory illness, poor impulse-control, unstable home environment, comorbid illness, greater impairment from conduct and substance problems etc.).